*Intermediate filaments, which are structurally similar to keratin, lend structure to a cell from within. These proteins of the extracellular matrix,like collagen, provide structure from outside the cell. Without Collagen the protein structure would not be as durable. (Essential Biochemistry)
*Trichoplein keratin filament-binding protein acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Trichoplein keratin filament-binding protein Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. (Q9BT92)
*Trichoplein keratin filament-binding protein acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Trichoplein keratin filament-binding protein Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. (Q9BT92)